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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | John Clarkson | 7.31 | 1882-1894 | |
| 2 | Bill Dinneen | 7.20 | 1898-1909 | |
| 3 | Tim Keefe | 6.79 | 1880-1893 | |
| 4 | Chief Bender* | 6.25 | 1903-1917 | |
| 5 | Orval Overall | 6.14 | 1905-1913 | |
| 6 | Bill Donovan | 5.94 | 1898-1918 | |
| 7 | Jack Coombs | 5.74 | 1906-1920 | |
| 8 | Satchel Paige# | 5.66 | 1933-1940 | |
| 8 | Carl Hubbell# | 5.66 | 1928-1941 | |
| 10 | George Mullin | 5.59 | 1902-1915 | |
| 11 | Jeff Tesreau | 5.57 | 1912-1918 | |
| 12 | Bill Hallahan | 5.51 | 1926-1938 | |
| 13 | Mordecai Brown* | 5.46 | 1903-1916 | |
| 14 | Rube Marquard* | 5.37 | 1908-1924 | |
| 15 | Eddie Plank* | 5.27 | 1901-1917 | |
| 16 | Ed Crane | 5.07 | 1884-1893 | |
| 17 | Mort Cooper# | 4.97 | 1938-1941 | |
| 18 | Willie Foster | 4.95 | 1931-1939 | |
| 19 | Roy Parmelee# | 4.83 | 1930-1940 | |
| 20 | Jim McCormick | 4.70 | 1878-1887 | |
| 21 | Silver King | 4.50 | 1886-1897 | |
| 21 | Ted Trent | 4.50 | 1937-1939 | |
| 23 | Rube Walberg | 4.35 | 1923-1936 | |
| 24 | Deacon Phillippe | 4.32 | 1899-1911 | |
| 25 | Bobo Newsom# | 4.29 | 1929-1941 | |
| 26 | Christy Mathewson* | 4.25 | 1900-1916 | |
| 27 | Jack Pfiester | 4.24 | 1903-1911 | |
| 28 | Hal Schumacher# | 4.20 | 1931-1941 | |
| 29 | Ted Lyons# | 4.19 | 1923-1941 | |
| 30 | Lefty Grove# | 4.12 | 1925-1941 | |
| 31 | Eddie Cicotte* | 4.03 | 1905-1920 | |
| 32 | Ernie Shore | 3.89 | 1912-1920 | |
| 33 | Cy Young* | 3.84 | 1890-1911 | |
| 34 | Dizzy Dean# | 3.71 | 1930-1941 | |
| 35 | George Earnshaw | 3.62 | 1928-1937 | |
| 36 | Bob Shawkey | 3.58 | 1913-1928 | |
| 36 | Ed Reulbach | 3.58 | 1905-1917 | |
| 38 | Tom Lovett | 3.55 | 1885-1894 | |
| 39 | Dave Foutz | 3.48 | 1884-1896 | |
| 40 | Jimmy Ring | 3.26 | 1917-1930 | |
| 41 | Bob Caruthers | 3.24 | 1884-1892 | |
| 42 | Adonis Terry | 3.19 | 1884-1897 | |
| 43 | Dutch Leonard | 3.14 | 1913-1927 | |
| 44 | Waite Hoyt | 3.06 | 1918-1940 | |
| 45 | Red Faber* | 3.02 | 1914-1931 | |
| 46 | Bill Lohrman# | 2.98 | 1935-1941 | |
| 46 | Bill Walker# | 2.98 | 1927-1938 | |
| 48 | Jesse Haines | 2.95 | 1918-1936 | |
| 49 | Paul Derringer# | 2.87 | 1931-1941 | |
| 50 | Pete Conway | 2.73 | 1885-1889 | |
| 51 | Ice Box Chamberlin | 2.66 | 1886-1896 | |
| 52 | Pretzels Getzien | 2.64 | 1884-1892 | |
| 53 | Babe Ruth | 2.32 | 1914-1937 | |
| 54 | Stan Coveleski | 2.30 | 1912-1927 | |
| 55 | Art Nehf | 2.23 | 1915-1930 | |
| 56 | Lefty Tyler | 2.18 | 1910-1924 | |
| 57 | Jack Quinn | 2.09 | 1909-1928 | |
| 58 | Burleigh Grimes | 2.05 | 1916-1932 | |
| 59 | Eppa Rixey* | 1.80 | 1912-1935 | |
| 60 | Sad Sam Jones | 1.52 | 1914-1936 | |
| 61 | Sherry Smith | 1.48 | 1911-1927 | |
| 62 | Lady Baldwin | 0.86 | 1884-1890 |
