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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Carl Hubbell# | 220 | 1928-1941 | |
| 2 | Jesse Haines | 219 | 1918-1936 | |
| 3 | Waite Hoyt | 215 | 1918-1940 | |
| 4 | Earl Whitehill | 210 | 1923-1940 | |
| 5 | Red Ruffing# | 208 | 1924-1941 | |
| 6 | Charlie Root# | 202 | 1923-1941 | |
| 7 | Lefty Grove# | 197 | 1925-1941 | |
| 8 | Ted Lyons# | 195 | 1923-1941 | |
| 9 | Freddie Fitzsimmons# | 188 | 1925-1941 | |
| 9 | Bill Sherdel | 188 | 1918-1932 | |
| 11 | Flint Rhem | 186 | 1924-1937 | |
| 12 | Willis Hudlin# | 184 | 1926-1941 | |
| 13 | Dazzy Vance | 183 | 1915-1937 | |
| 14 | Lon Warneke# | 182 | 1930-1941 | |
| 15 | Bump Hadley | 181 | 1926-1940 | |
| 16 | George Uhle | 176 | 1919-1936 | |
| 17 | Danny MacFayden# | 174 | 1926-1940 | |
| 18 | Tommy Bridges# | 169 | 1930-1941 | |
| 18 | Firpo Marberry | 169 | 1923-1936 | |
| 20 | Rube Walberg | 168 | 1923-1936 | |
| 21 | Tom Zachary | 167 | 1918-1938 | |
| 22 | Wes Ferrell# | 164 | 1927-1940 | |
| 23 | Howard Ehmke | 163 | 1915-1932 | |
| 24 | John Clarkson | 161 | 1882-1894 | |
| 24 | Bill Hallahan | 161 | 1926-1938 | |
| 26 | Terris McDuffie# | 160 | 1933-1941 | |
| 27 | Burleigh Grimes | 159 | 1916-1932 | |
| 28 | Kid Nichols* | 156 | 1890-1906 | |
| 29 | Vic Aldridge | 154 | 1917-1930 | |
| 30 | Herb Pennock | 153 | 1912-1934 | |
| 30 | Bill V Swift# | 153 | 1932-1941 | |
| 32 | General Crowder | 150 | 1926-1936 | |
| 33 | Red Lucas | 149 | 1924-1940 | |
| 34 | Jimmy Ring | 148 | 1917-1930 | |
| 35 | Sad Sam Jones | 145 | 1914-1936 | |
| 36 | Walter Johnson* | 141 | 1907-1930 | |
| 37 | Sam Gray | 139 | 1924-1934 | |
| 38 | Cy Young* | 138 | 1890-1911 | |
| 39 | Bill Doak | 136 | 1912-1929 | |
| 40 | Luke Hamlin# | 134 | 1934-1941 | |
| 40 | Van Mungo# | 134 | 1931-1941 | |
| 42 | Rip Collins | 133 | 1920-1933 | |
| 42 | Dizzy Dean# | 133 | 1930-1941 | |
| 44 | Eppa Rixey* | 132 | 1912-1935 | |
| 45 | Dutch E Leonard# | 131 | 1933-1941 | |
| 45 | Pat Malone | 131 | 1928-1937 | |
| 45 | Jack Stivetts | 131 | 1889-1899 | |
| 48 | Red Faber* | 128 | 1914-1931 | |
| 48 | Schoolboy Rowe# | 128 | 1933-1941 | |
| 50 | Sheriff Blake | 126 | 1920-1936 | |
| 50 | Bill C Lee# | 126 | 1934-1941 | |
| 52 | Mel Harder# | 125 | 1928-1941 | |
| 52 | Si Johnson# | 125 | 1929-1941 | |
| 52 | Syl Johnson# | 125 | 1929-1940 | |
| 52 | Dolf Luque | 125 | 1914-1934 | |
| 52 | Hugh McQuillan | 125 | 1918-1931 | |
| 52 | Art Nehf | 125 | 1915-1930 | |
| 52 | Bobo Newsom# | 125 | 1929-1941 | |
| 59 | Tex Carleton# | 124 | 1932-1941 | |
| 59 | Johnny Morrison | 124 | 1920-1931 | |
| 61 | Paul Derringer# | 123 | 1931-1941 | |
| 62 | Pud Galvin | 122 | 1875-1892 | |
| 63 | Lefty Stewart | 121 | 1921-1934 | |
| 64 | William Bell | 120 | 1933-1937 | |
| 64 | Gus Weyhing | 120 | 1887-1901 | |
| 66 | Thornton Lee# | 119 | 1933-1941 | |
| 66 | George Pipgras | 119 | 1923-1936 | |
| 68 | Ben Cantwell# | 117 | 1927-1940 | |
| 68 | Old Hoss Radbourn | 117 | 1881-1891 | |
| 70 | Snipe Hansen | 115 | 1930-1937 | |
| 71 | George Earnshaw | 114 | 1928-1937 | |
| 71 | Urban Shocker | 114 | 1916-1927 | |
| 71 | Monty Stratton | 114 | 1934-1940 | |
| 71 | Bill Walker# | 114 | 1927-1938 | |
| 75 | Harry Holsclaw | 113 | 1924-1938 | |
| 75 | Vic Sorrell | 113 | 1928-1936 | |
| 77 | Lee Meadows | 112 | 1915-1929 | |
| 77 | Bob Shawkey | 112 | 1913-1928 | |
| 79 | Jesse Petty | 111 | 1921-1933 | |
| 79 | Jack Scott | 111 | 1916-1929 | |
| 81 | Jack J Powell | 110 | 1897-1912 | |
| 81 | Whit Wyatt# | 110 | 1929-1941 | |
| 83 | Frank Dwyer | 109 | 1888-1899 | |
| 84 | Bill Holland# | 108 | 1937-1941 | |
| 85 | Clint Brown# | 107 | 1928-1941 | |
| 85 | Fred Frankhouse | 107 | 1927-1939 | |
| 85 | Bob Smith | 107 | 1926-1936 | |
| 88 | Dixie Davis | 106 | 1912-1926 | |
| 88 | Ed Durham | 106 | 1929-1935 | |
| 88 | Mickey Welch | 106 | 1880-1892 | |
| 91 | Bullet Joe Bush | 105 | 1912-1928 | |
| 91 | Fred Heimach | 105 | 1920-1936 | |
| 93 | Johnny Allen# | 104 | 1932-1941 | |
| 93 | Guy Bush | 104 | 1923-1939 | |
| 93 | Watty Clark | 104 | 1925-1938 | |
| 93 | Bill Hutchinson | 104 | 1884-1897 | |
| 93 | Tommy Thomas | 104 | 1926-1936 | |
| 98 | Ray Kremer | 100 | 1924-1934 | |
| 98 | Bob Weiland# | 100 | 1929-1941 | |
| 100 | Pete Alexander* | 99 | 1911-1929 |
