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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Ed Walsh* | 1.816 | 1904-1917 | |
| 2 | Addie Joss | 1.887 | 1902-1910 | |
| 3 | Jack Pfiester | 2.024 | 1903-1911 | |
| 4 | Smoky Joe Wood | 2.030 | 1908-1925 | |
| 5 | Jim A Devlin | 2.050 | 1875-1877 | |
| 6 | Mordecai Brown* | 2.057 | 1903-1916 | |
| 7 | Monte Ward | 2.102 | 1878-1894 | |
| 8 | Christy Mathewson* | 2.133 | 1900-1916 | |
| 9 | Al Spalding | 2.136 | 1871-1877 | |
| 10 | Rube Waddell* | 2.161 | 1897-1910 | |
| 11 | Babe Ruth | 2.200 | 1914-1937 | |
| 12 | Jake Weimer | 2.231 | 1903-1909 | |
| 13 | Orval Overall | 2.233 | 1905-1913 | |
| 14 | Will White | 2.276 | 1877-1886 | |
| 15 | Ed Reulbach | 2.284 | 1905-1917 | |
| 16 | Jim Scott | 2.298 | 1909-1917 | |
| 17 | Walter Johnson* | 2.309 | 1907-1930 | |
| 18 | Tommy Bond | 2.312 | 1874-1884 | |
| 19 | Reb Russell | 2.334 | 1913-1919 | |
| 20 | Andy Coakley | 2.350 | 1902-1911 | |
| 20 | Eddie Plank* | 2.350 | 1901-1917 | |
| 22 | Pete Alexander* | 2.352 | 1911-1929 | |
| 23 | Larry Corcoran | 2.355 | 1880-1887 | |
| 24 | George McQuillan | 2.381 | 1907-1918 | |
| 25 | Eddie Cicotte* | 2.382 | 1905-1920 | |
| 25 | Ed Killian | 2.382 | 1903-1910 | |
| 27 | Doc White | 2.391 | 1901-1913 | |
| 28 | Harry Coveleski | 2.394 | 1907-1918 | |
| 29 | Carl Lundgren | 2.417 | 1902-1909 | |
| 30 | George Bradley | 2.418 | 1875-1884 | |
| 31 | Nap Rucker | 2.421 | 1907-1916 | |
| 32 | Ed Summers | 2.423 | 1908-1912 | |
| 33 | Jeff Tesreau | 2.428 | 1912-1918 | |
| 34 | Joe Benz | 2.429 | 1911-1919 | |
| 35 | Jim McCormick | 2.431 | 1878-1887 | |
| 36 | Terry Larkin | 2.435 | 1876-1880 | |
| 37 | Chief Bender* | 2.450 | 1903-1917 | |
| 38 | Hooks Wiltse | 2.471 | 1904-1915 | |
| 39 | Ernie Shore | 2.472 | 1912-1920 | |
| 40 | Sam Leever | 2.473 | 1898-1910 | |
| 40 | Lefty Leifield | 2.473 | 1905-1920 | |
| 42 | Candy Cummings | 2.491 | 1872-1877 | |
| 43 | Bob Ewing | 2.492 | 1902-1912 | |
| 44 | Cy Morgan | 2.509 | 1903-1913 | |
| 45 | Ray Collins | 2.513 | 1909-1915 | |
| 46 | Fred Toney | 2.530 | 1911-1925 | |
| 47 | Lew Richie | 2.536 | 1906-1913 | |
| 48 | Noodles Hahn | 2.546 | 1899-1906 | |
| 49 | Frank Owen | 2.552 | 1901-1909 | |
| 50 | Deacon Phillippe | 2.586 | 1899-1911 | |
| 51 | Russ Ford | 2.590 | 1909-1915 | |
| 52 | Hod Eller | 2.593 | 1917-1921 | |
| 52 | Frank E Smith | 2.593 | 1904-1915 | |
| 54 | Ed Siever | 2.598 | 1901-1908 | |
| 55 | Bob Rhoads | 2.612 | 1902-1909 | |
| 56 | Fred Glade | 2.618 | 1902-1908 | |
| 57 | Vean Gregg | 2.621 | 1911-1918 | |
| 58 | Tim Keefe | 2.625 | 1880-1893 | |
| 58 | Dick Rudolph | 2.625 | 1910-1923 | |
| 60 | Cy Young* | 2.627 | 1890-1911 | |
| 61 | Vic Willis | 2.628 | 1898-1910 | |
| 62 | Red Ames | 2.629 | 1903-1919 | |
| 63 | Barney Pelty | 2.632 | 1903-1912 | |
| 64 | Jimmy Dygert | 2.647 | 1905-1910 | |
| 65 | Nick Altrock | 2.649 | 1898-1919 | |
| 65 | Claude Hendrix | 2.649 | 1911-1920 | |
| 67 | Joe McGinnity | 2.657 | 1899-1908 | |
| 68 | Jack W Taylor | 2.662 | 1898-1907 | |
| 69 | Pete Schneider | 2.663 | 1914-1919 | |
| 70 | Carl Weilman | 2.669 | 1912-1920 | |
| 71 | Babe Adams | 2.670 | 1906-1927 | |
| 72 | Charlie J Ferguson | 2.674 | 1884-1887 | |
| 73 | Old Hoss Radbourn | 2.675 | 1881-1891 | |
| 74 | Johnny Lush | 2.680 | 1904-1910 | |
| 75 | Cy Falkenberg | 2.682 | 1903-1917 | |
| 76 | Jack Chesbro | 2.684 | 1899-1909 | |
| 77 | Hippo Vaughn* | 2.686 | 1908-1925 | |
| 78 | Bill Donovan | 2.690 | 1898-1918 | |
| 79 | Larry Cheney | 2.698 | 1911-1919 | |
| 80 | Nick Cullop | 2.707 | 1913-1922 | |
| 81 | Mickey Welch | 2.712 | 1880-1892 | |
| 82 | Ned Garvin | 2.718 | 1896-1904 | |
| 83 | Bob Wicker | 2.726 | 1901-1906 | |
| 84 | Fred Goldsmith | 2.729 | 1879-1884 | |
| 85 | Carl Hubbell# | 2.734 | 1928-1941 | |
| 86 | Harry Howell | 2.738 | 1898-1910 | |
| 87 | Slim Sallee | 2.744 | 1908-1924 | |
| 88 | Mike Prendergast | 2.745 | 1914-1919 | |
| 89 | Dummy Taylor | 2.747 | 1900-1908 | |
| 90 | Howie Camnitz | 2.749 | 1904-1915 | |
| 90 | Roy Patterson | 2.749 | 1901-1907 | |
| 92 | Carl Mays | 2.752 | 1915-1928 | |
| 93 | Jeff Pfeffer | 2.771 | 1911-1924 | |
| 94 | Al Demaree | 2.775 | 1912-1919 | |
| 94 | Earl Moore | 2.775 | 1901-1914 | |
| 96 | George Zettlein | 2.776 | 1871-1876 | |
| 97 | Jack Coombs | 2.781 | 1906-1920 | |
| 98 | Ed Karger | 2.787 | 1906-1911 | |
| 99 | Jesse Tannehill | 2.788 | 1894-1911 | |
| 100 | Rube Marquard* | 2.792 | 1908-1924 |
