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| Saturday, July 19th, 1941 |
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| Traded 29-year-old left fielder Joe Medwick to the Washington Senators, getting 42-year-old reliever Bill M Harris, 23-year-old starting pitcher Jess Dobernic and 22-year-old left fielder Jim Mallory in return. |
| Monday, June 23rd, 1941 |
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| Placed C Don Padgett on the 15-day injured list, retroactive to 06/22/1941. |
| Monday, June 16th, 1941 |
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| Traded 26-year-old catcher Walker Cooper and 20-year-old center fielder Erv Dusak to the Chicago Cubs, getting 32-year-old starting pitcher Lon Warneke and 21-year-old first baseman Eddie Waitkus in return. |
| Sunday, June 15th, 1941 |
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| Placed CL Johnny Beazley on the 15-day injured list, retroactive to 06/14/1941. |
| Tuesday, May 27th, 1941 |
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| Placed SP Paul Derringer on the 60-day injured list. |
| Wednesday, May 14th, 1941 |
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| Activated CF Stan Musial from the injured list. |
| Tuesday, April 22nd, 1941 |
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| Activated 3B Whitey Kurowski from the injured list. |
| Activated RP Rip Sewell from the injured list. |
| Monday, April 7th, 1941 |
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| Placed RP Rip Sewell on the 15-day injured list, retroactive to 04/06/1941. |
| Sunday, March 30th, 1941 |
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| Placed CF Stan Musial on the 15-day injured list, retroactive to 03/29/1941. |
| Friday, March 21st, 1941 |
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| Placed 3B Whitey Kurowski on the 15-day injured list, retroactive to 03/20/1941. |
| Tuesday, December 31st, 1940 |
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| Traded 24-year-old reliever Sam Page to the Boston Red Sox, getting 36-year-old closer Jack Russell in return. |
| Sunday, December 22nd, 1940 |
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| Traded 24-year-old reliever Joe Callahan to the St. Louis Browns, getting 33-year-old closer Rip Sewell in return. |
| Sunday, October 20th, 1940 |
|---|
| Activated SP Max Lanier from the injured list. |
| Signed RP Johnny Beazley. |
| Signed CF Erv Dusak. |
| Signed RP Hank Gornicki. |
| Signed RP Johnny Grodzicki. |
| Signed 3B Whitey Kurowski. |
| Signed RP Hersh Lyons. |
| Signed RF Stan Musial. |
| Signed SP Howie Pollet. |
| Signed RF Walter Sessi. |
