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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | RBI | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Jimmie Foxx# | 191 | 1929 | |
| 2 | Babe Ruth | 186 | 1923 | |
| 3 | Babe Ruth | 185 | 1925 | |
| 4 | Chuck Klein# | 170 | 1930 | |
| 5 | Mel Ott# | 168 | 1930 | |
| 5 | Lou Gehrig# | 168 | 1929 | |
| 7 | Sam Thompson | 166 | 1887 | |
| 7 | Mel Ott# | 166 | 1934 | |
| 9 | Sam Thompson | 165 | 1895 | |
| 10 | Babe Ruth | 162 | 1921 | |
| 10 | Babe Ruth | 162 | 1934 | |
| 12 | Lou Gehrig# | 161 | 1927 | |
| 13 | Lou Gehrig# | 157 | 1930 | |
| 14 | Lou Gehrig# | 152 | 1935 | |
| 15 | Johnny Mize# | 150 | 1940 | |
| 16 | Lou Gehrig# | 149 | 1937 | |
| 17 | Babe Ruth | 148 | 1924 | |
| 18 | Cap Anson | 147 | 1886 | |
| 18 | Jimmie Foxx# | 147 | 1930 | |
| 20 | Chuck Klein# | 146 | 1932 | |
| 20 | Hardy Richardson | 146 | 1890 | |
| 20 | Joe Hauser | 146 | 1925 | |
| 20 | Ed Delahanty | 146 | 1893 | |
| 24 | Joe Hauser | 145 | 1924 | |
| 24 | Hugh Duffy | 145 | 1894 | |
| 24 | Lou Gehrig# | 145 | 1936 | |
| 27 | Jimmie Foxx# | 144 | 1932 | |
| 28 | Jack Fournier | 143 | 1921 | |
| 29 | Lou Gehrig# | 142 | 1928 | |
| 29 | Lou Gehrig# | 142 | 1934 | |
| 31 | Dale Alexander | 141 | 1929 | |
| 31 | Sam Thompson | 141 | 1894 | |
| 31 | Al Simmons# | 141 | 1929 | |
| 31 | Hank Greenberg# | 141 | 1939 | |
| 31 | Babe Ruth | 141 | 1930 | |
| 31 | Johnny Mize# | 141 | 1938 | |
| 31 | Johnny Mize# | 141 | 1937 | |
| 38 | Al Simmons# | 140 | 1932 | |
| 38 | Hank Greenberg# | 140 | 1938 | |
| 38 | Mel Ott# | 140 | 1938 | |
| 38 | Bibb Falk | 140 | 1925 | |
| 42 | Hal Trosky Sr# | 139 | 1937 | |
| 42 | Chuck Klein# | 139 | 1928 | |
| 42 | Jimmie Foxx# | 139 | 1936 | |
| 42 | Lou Gehrig# | 139 | 1925 | |
| 42 | Lou Gehrig# | 139 | 1938 | |
| 42 | Goose Goslin | 139 | 1927 | |
| 48 | Mel Ott# | 138 | 1932 | |
| 49 | Mel Ott# | 137 | 1929 | |
| 49 | Joe Medwick# | 137 | 1938 | |
| 49 | Babe Ruth | 137 | 1920 | |
| 49 | Ed Delahanty | 137 | 1899 | |
| 53 | George Davis | 136 | 1897 | |
| 53 | Hal Trosky Sr# | 136 | 1936 | |
| 53 | Adam Comorosky | 136 | 1930 | |
| 53 | Hack Wilson | 136 | 1929 | |
| 53 | Hack Wilson | 136 | 1930 | |
| 58 | Bill Dickey# | 135 | 1935 | |
| 58 | Red Rolfe# | 135 | 1938 | |
| 58 | Jimmie Foxx# | 135 | 1937 | |
| 58 | Hank Greenberg# | 135 | 1937 | |
| 62 | Bobby Veach | 134 | 1921 | |
| 62 | Johnny Mize# | 134 | 1936 | |
| 62 | Don Hurst | 134 | 1930 | |
| 62 | Hack Wilson | 134 | 1925 | |
| 62 | Joe Kelley | 134 | 1895 | |
| 62 | Babe Ruth | 134 | 1928 | |
| 62 | Hank Greenberg# | 134 | 1940 | |
| 62 | Jimmie Foxx# | 134 | 1933 | |
| 62 | Steve Brodie | 134 | 1895 | |
| 71 | Goose Goslin | 133 | 1930 | |
| 71 | Ed McKean | 133 | 1893 | |
| 71 | Ken Williams | 133 | 1921 | |
| 74 | Jimmy Collins | 132 | 1897 | |
| 75 | Ed Delahanty | 131 | 1894 | |
| 75 | Del Bissonette | 131 | 1930 | |
| 77 | Jim Bottomley | 130 | 1930 | |
| 77 | Home Run Baker* | 130 | 1912 | |
| 77 | George Grantham | 130 | 1927 | |
| 77 | Walt Wilmot | 130 | 1894 | |
| 77 | Roger Connor | 130 | 1889 | |
| 82 | Jimmie Foxx# | 129 | 1935 | |
| 82 | Hugh Duffy | 129 | 1897 | |
| 82 | Rogers Hornsby* | 129 | 1921 | |
| 85 | Babe Ruth | 128 | 1935 | |
| 85 | Ed McKean | 128 | 1894 | |
| 85 | Zeke Bonura# | 128 | 1936 | |
| 85 | Earle Combs | 128 | 1925 | |
| 85 | Gavvy Cravath | 128 | 1913 | |
| 85 | Hal Trosky Sr# | 128 | 1934 | |
| 85 | Oyster Burns | 128 | 1890 | |
| 85 | Dan Brouthers | 128 | 1894 | |
| 93 | Les Bell | 127 | 1925 | |
| 93 | Hal Trosky Sr# | 127 | 1940 | |
| 93 | Ty Cobb* | 127 | 1911 | |
| 93 | Nap Lajoie* | 127 | 1897 | |
| 93 | Hank Leiber# | 127 | 1938 | |
| 93 | Nap Lajoie* | 127 | 1898 | |
| 93 | Mel Ott# | 127 | 1937 | |
| 93 | Ripper Collins# | 127 | 1935 |
