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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | L | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Walter Johnson* | 318 | 1907-1930 | |
| 2 | Cy Young* | 316 | 1890-1911 | |
| 3 | Pud Galvin | 310 | 1875-1892 | |
| 4 | Eppa Rixey* | 293 | 1912-1935 | |
| 5 | Herb Pennock | 281 | 1912-1934 | |
| 6 | Jack J Powell | 254 | 1897-1912 | |
| 7 | Bobby Mathews | 248 | 1871-1887 | |
| 8 | Waite Hoyt | 233 | 1918-1940 | |
| 9 | Gus Weyhing | 232 | 1887-1901 | |
| 10 | Red Ruffing# | 226 | 1924-1941 | |
| 11 | Tim Keefe | 225 | 1880-1893 | |
| 11 | Lee Meadows | 225 | 1915-1929 | |
| 13 | Tony Mullane | 220 | 1881-1894 | |
| 14 | George Uhle | 217 | 1919-1936 | |
| 15 | Sad Sam Jones | 215 | 1914-1936 | |
| 16 | Ted Lyons# | 214 | 1923-1941 | |
| 16 | Jim McCormick | 214 | 1878-1887 | |
| 18 | Bullet Joe Bush | 212 | 1912-1928 | |
| 18 | Freddie Fitzsimmons# | 212 | 1925-1941 | |
| 18 | Chick Fraser | 212 | 1896-1909 | |
| 21 | Earl Whitehill | 211 | 1923-1940 | |
| 22 | Mickey Welch | 210 | 1880-1892 | |
| 23 | Kid Nichols* | 208 | 1890-1906 | |
| 24 | Red Faber* | 207 | 1914-1931 | |
| 25 | Bill Doak | 205 | 1912-1929 | |
| 25 | Burleigh Grimes | 205 | 1916-1932 | |
| 25 | Danny MacFayden# | 205 | 1926-1940 | |
| 25 | Vic Willis | 205 | 1898-1910 | |
| 29 | Jim Whitney | 204 | 1881-1890 | |
| 30 | Jesse Haines | 203 | 1918-1936 | |
| 31 | Dazzy Vance | 202 | 1915-1937 | |
| 32 | George Mullin | 196 | 1902-1915 | |
| 32 | Adonis Terry | 196 | 1884-1897 | |
| 34 | Old Hoss Radbourn | 195 | 1881-1891 | |
| 34 | Bill Sherdel | 195 | 1918-1932 | |
| 36 | Eddie Plank* | 194 | 1901-1917 | |
| 36 | Jimmy Ring | 194 | 1917-1930 | |
| 38 | Bump Hadley | 192 | 1926-1940 | |
| 39 | Al Orth | 189 | 1895-1909 | |
| 40 | Christy Mathewson* | 188 | 1900-1916 | |
| 41 | Charlie Root# | 181 | 1923-1941 | |
| 42 | Pink Hawley | 179 | 1892-1901 | |
| 42 | Hippo Vaughn* | 179 | 1908-1925 | |
| 44 | John Clarkson | 178 | 1882-1894 | |
| 44 | Willis Hudlin# | 178 | 1926-1941 | |
| 46 | Rube Benton | 177 | 1910-1930 | |
| 46 | Bill Dinneen | 177 | 1898-1909 | |
| 46 | Dolf Luque | 177 | 1914-1934 | |
| 46 | Jack Quinn | 177 | 1909-1928 | |
| 50 | Wes Ferrell# | 176 | 1927-1940 | |
| 51 | Red Donahue | 175 | 1893-1906 | |
| 51 | Tom J Hughes | 175 | 1900-1913 | |
| 53 | Amos Rusie | 174 | 1889-1901 | |
| 54 | Ted Breitenstein | 170 | 1891-1901 | |
| 54 | Tom Zachary | 170 | 1918-1938 | |
| 56 | Red Ames | 167 | 1903-1919 | |
| 56 | Bert Cunningham | 167 | 1887-1901 | |
| 56 | Red Ehret | 167 | 1888-1898 | |
| 59 | Will White | 166 | 1877-1886 | |
| 60 | Mark Baldwin | 165 | 1887-1893 | |
| 61 | Win Mercer | 164 | 1894-1902 | |
| 62 | Tommy Bond | 163 | 1874-1884 | |
| 62 | Bill Hutchinson | 163 | 1884-1897 | |
| 64 | Hooks Dauss | 161 | 1912-1924 | |
| 64 | Howard Ehmke | 161 | 1915-1932 | |
| 66 | Bob Shawkey | 160 | 1913-1928 | |
| 67 | Mel Harder# | 159 | 1928-1941 | |
| 67 | Brickyard Kennedy | 159 | 1892-1903 | |
| 69 | Wilbur Cooper | 156 | 1912-1926 | |
| 69 | Slim Sallee | 156 | 1908-1924 | |
| 69 | Doc White | 156 | 1901-1913 | |
| 69 | Stump Wiedman | 156 | 1880-1888 | |
| 73 | Rip Collins | 154 | 1920-1933 | |
| 73 | Lefty Grove# | 154 | 1925-1941 | |
| 73 | Silver King | 154 | 1886-1897 | |
| 73 | Earl Moore | 154 | 1901-1914 | |
| 73 | Lon Warneke# | 154 | 1930-1941 | |
| 78 | Charlie Buffinton | 152 | 1882-1892 | |
| 78 | Frank Dwyer | 152 | 1888-1899 | |
| 80 | George Bradley | 151 | 1875-1884 | |
| 80 | Jakie May | 151 | 1917-1934 | |
| 82 | Bob Groom | 150 | 1909-1918 | |
| 82 | George Pipgras | 150 | 1923-1936 | |
| 84 | Eddie Cicotte* | 149 | 1905-1920 | |
| 84 | Art Nehf | 149 | 1915-1930 | |
| 86 | Bill Hallahan | 148 | 1926-1938 | |
| 87 | Rube Marquard* | 147 | 1908-1924 | |
| 88 | Clark Griffith | 146 | 1891-1914 | |
| 88 | Guy Hecker | 146 | 1882-1890 | |
| 88 | Harry Howell | 146 | 1898-1910 | |
| 88 | Firpo Marberry | 146 | 1923-1936 | |
| 92 | Ben Cantwell# | 145 | 1927-1940 | |
| 93 | Pete Alexander* | 144 | 1911-1929 | |
| 93 | Red Lucas | 144 | 1924-1940 | |
| 95 | Vic Aldridge | 143 | 1917-1930 | |
| 95 | Flint Rhem | 143 | 1924-1937 | |
| 95 | Rube Waddell* | 143 | 1897-1910 | |
| 95 | Rube Walberg | 143 | 1923-1936 | |
| 99 | Sheriff Blake | 142 | 1920-1936 | |
| 99 | Earl Hamilton | 142 | 1911-1924 |
