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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Babe Ruth | 774 | 1914-1937 | |
| 2 | Lou Gehrig# | 612 | 1923-1941 | |
| 3 | Jimmie Foxx# | 564 | 1925-1941 | |
| 4 | Mel Ott# | 510 | 1926-1941 | |
| 5 | Chuck Klein# | 365 | 1928-1940 | |
| 6 | Rogers Hornsby* | 330 | 1915-1935 | |
| 6 | Al Simmons# | 330 | 1924-1941 | |
| 8 | Hank Greenberg# | 322 | 1931-1941 | |
| 9 | Gabby Hartnett# | 314 | 1922-1941 | |
| 10 | Hack Wilson | 303 | 1923-1937 | |
| 11 | Goose Goslin | 274 | 1921-1940 | |
| 12 | Hal Trosky Sr# | 270 | 1933-1941 | |
| 13 | Babe Herman# | 265 | 1926-1938 | |
| 14 | Cy Williams | 239 | 1912-1930 | |
| 15 | Jim Bottomley | 225 | 1922-1939 | |
| 16 | Bill Dickey# | 220 | 1928-1941 | |
| 17 | Charlie Gehringer# | 215 | 1924-1941 | |
| 18 | Johnny Mize# | 214 | 1936-1941 | |
| 19 | Ripper Collins# | 205 | 1931-1941 | |
| 20 | Joe Medwick# | 185 | 1932-1941 | |
| 21 | Bill Terry | 178 | 1923-1938 | |
| 22 | Travis Jackson | 173 | 1922-1938 | |
| 22 | Rudy York# | 173 | 1934-1941 | |
| 24 | Harlond Clift# | 156 | 1934-1941 | |
| 24 | Kiki Cuyler | 156 | 1921-1937 | |
| 26 | Joe Hauser | 150 | 1922-1930 | |
| 27 | George Selkirk# | 145 | 1934-1941 | |
| 28 | Hank Leiber# | 144 | 1933-1941 | |
| 29 | Don Hurst | 142 | 1928-1938 | |
| 30 | Roger Connor | 138 | 1880-1897 | |
| 31 | Jimmy Dykes | 133 | 1918-1939 | |
| 32 | Dolph Camilli# | 131 | 1931-1941 | |
| 33 | Zeke Bonura# | 130 | 1934-1941 | |
| 34 | Sam Thompson | 127 | 1885-1906 | |
| 34 | Zack Wheat | 127 | 1909-1930 | |
| 36 | Pinky Whitney# | 125 | 1928-1941 | |
| 37 | Marty McManus | 123 | 1920-1935 | |
| 38 | Harry Stovey | 122 | 1880-1893 | |
| 39 | Mule Suttles# | 121 | 1933-1941 | |
| 39 | Glenn Wright | 121 | 1924-1934 | |
| 41 | Ival Goodman# | 120 | 1935-1941 | |
| 42 | Ty Cobb* | 119 | 1905-1929 | |
| 42 | Gavvy Cravath | 119 | 1908-1920 | |
| 44 | Heinie Manush | 118 | 1923-1938 | |
| 44 | Jimmy Ryan | 118 | 1885-1903 | |
| 44 | Gee Walker# | 118 | 1931-1941 | |
| 47 | Mickey Cochrane | 116 | 1927-1939 | |
| 47 | Frankie Frisch | 116 | 1919-1937 | |
| 47 | Tommy Henrich# | 116 | 1937-1941 | |
| 50 | Home Run Baker* | 114 | 1908-1925 | |
| 50 | Bruce Campbell# | 114 | 1930-1941 | |
| 50 | Joe Kuhel# | 114 | 1930-1941 | |
| 53 | Bing Miller | 113 | 1921-1936 | |
| 54 | Freddie Lindstrom | 112 | 1924-1937 | |
| 54 | John Stone | 112 | 1928-1940 | |
| 56 | Russ Wrightstone | 111 | 1920-1930 | |
| 57 | Eric McNair# | 108 | 1929-1941 | |
| 57 | Tillie Walker | 108 | 1911-1926 | |
| 59 | Dan Brouthers | 106 | 1879-1904 | |
| 59 | Hugh Duffy | 106 | 1888-1906 | |
| 59 | Mike Tiernan | 106 | 1887-1899 | |
| 62 | George Sisler* | 103 | 1915-1931 | |
| 63 | Tony Cuccinello# | 102 | 1930-1941 | |
| 63 | Irish Meusel | 102 | 1914-1927 | |
| 65 | Ed Delahanty | 101 | 1888-1903 | |
| 65 | Honus Wagner* | 101 | 1897-1917 | |
| 67 | Cap Anson | 97 | 1871-1897 | |
| 67 | Sam Crawford* | 97 | 1899-1917 | |
| 69 | Johnny Moore# | 96 | 1932-1940 | |
| 70 | Les Bell | 95 | 1923-1934 | |
| 70 | Bob O'Farrell | 95 | 1915-1934 | |
| 70 | Tris Speaker* | 95 | 1907-1929 | |
| 70 | Paul Waner# | 95 | 1926-1941 | |
| 70 | Ken Williams | 95 | 1915-1930 | |
| 75 | Odell Hale# | 94 | 1931-1941 | |
| 75 | Shanty Hogan | 94 | 1925-1938 | |
| 75 | Fred Pfeffer | 94 | 1882-1897 | |
| 78 | Frank Schulte | 92 | 1904-1918 | |
| 79 | Herman Long | 91 | 1889-1904 | |
| 80 | Cliff W Lee | 90 | 1919-1927 | |
| 80 | Elmer Smith | 90 | 1914-1925 | |
| 82 | Lonny Frey# | 89 | 1933-1941 | |
| 83 | Johnny Frederick# | 88 | 1929-1934 | |
| 83 | Augie Galan# | 88 | 1934-1941 | |
| 83 | Joe Judge | 88 | 1915-1932 | |
| 86 | Jo-Jo Moore# | 87 | 1930-1940 | |
| 87 | Jake Beckley | 86 | 1888-1907 | |
| 87 | Ben Chapman# | 86 | 1930-1941 | |
| 87 | Chet Laabs# | 86 | 1937-1941 | |
| 87 | Phil Todt | 86 | 1924-1937 | |
| 91 | Ken Keltner# | 85 | 1937-1941 | |
| 92 | Bill Dahlen | 84 | 1891-1911 | |
| 92 | Fred Luderus | 84 | 1909-1920 | |
| 94 | Del Bissonette | 83 | 1928-1935 | |
| 94 | George Grantham | 83 | 1922-1936 | |
| 94 | Pinky Higgins# | 83 | 1930-1941 | |
| 94 | Nap Lajoie* | 83 | 1896-1916 | |
| 94 | Sherry Magee | 83 | 1904-1919 | |
| 99 | Buck J Freeman | 82 | 1891-1907 | |
| 100 | Billy Werber# | 81 | 1930-1941 |
